After confirming the prognostic significance and the critical role for the immune microenvironment of cuproptosis genes, we constructed a scoring model entitled CuproScore based on the 4 cuproptosis genes (which consist of FDX1, LIAS, PDHB, and MTF1) to measure the level of cuproptosis in ccRCC. This evidence concerns the gene FDX1 and nonpapillary renal cell carcinoma.