Figure 6A displays that FDX1 and PDHB were considerably downregulated in the tumors. Furthermore, we classified the Taizhou cohort into two clusters, A and B, based on gene expression patterns. Here, patients in cluster B had a worse prognosis (Figure 6B), which validated the clustering strategy of ccRCC. Based on the formula for Cuproscore model, we partitioned the Taizhou cohort into the high- and low-risk groups, and the results of KM analysis showed that those in the high-risk group suffer a worse prognosis (Figure 6C), which was consistent with the KIRC cohort from the datasets. The gene discussed is PDHB; the disease is nonpapillary renal cell carcinoma.