Cox regression analysis disclosed that FDX1, LIAS, DLD, DLAT, PDHB, MTF1, CDKN2A, ATP7B, and SLC31A1 were critical preventive factors for ccRCC, while CDKN2A acted as a risk factor (Figure 1B). The gene discussed is MTF1; the disease is nonpapillary renal cell carcinoma.