On one hand, hypoxic cancer cells and vascular endothelial cells release VEGF that favors angiogenesis, tumor growth, invasion, and metastasis; on the other, VEGF induces the mobilization and proliferation of various cells, including regulatory T cells (Tregs), the release of immunosuppressive cytokines, thus leading to immune escape (7). The gene discussed is VEGFA; the disease is neoplasm.