In the presence of Nrf2 inducers, Nrf2 is liberated from Keap, translocates to the nucleus, and forms a heterodimer with small masculoaponeurotic fibrosarcoma (Maf) binding to the Antioxidant Response Element (ARE), a cis-acting enhancer sequence (TCAG/CXXXGC) (15, 18, 19). This evidence concerns the gene NFE2L2 and fibrosarcoma.