Specifically, we previously analyzed the anti-tumor effect of zaltoprofen, a nonsteroidal anti-inflammatory drug (NSAID), via peroxisome proliferator-activated receptor gamma (PPARγ) in some musculoskeletal tumors, including TGCT (10), giant cell tumor of bone (11) and chondrosarcoma (12). The gene discussed is PPARG; the disease is chondrosarcoma.