ICAM1 and brain inflammatory disease: The expression of the integrin lymphocyte function-associated antigen 1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) in naïve macrophage sEVs mediated the uptake of exosomes in brain endothelial cells, thereby helping sEVs deliver brain-derived neurotrophic factor (BNDF) to the brain, especially in the presence of brain inflammation.