CD8A and neoplasm: The proportion of CD8+ T-cells increased after WJR treatment, suggesting that WJR can play a role in tumor cytotoxicity by mobilizing the cellular immune system. IFN-γ is a pleiotropic cytokine, mainly produced by Th1 cells, NK cells, and cytotoxic T cells, which is involved in tumor clearance, dormancy, escape, and progression (28).