HAVCR2 and subcutaneous panniculitis-like T-cell lymphoma: Recently, a few of documents indicate that SPTCL is a genetically distinct disease with highly frequent HAVCR2(TIM-3) gene mutation (5, 6, 12).It have been shown that HAVCR2 mutations happened to 59% of familial SPTCL (5) and 85% of sporadic Asian patients (6).