As TIM-3 gene’s the second mutant locus(Arg89Cys),it is a novel variant and different from reported 3 cases with compound heterozygous mutations on TIM-3 gene in SPTCL(2 for Ile97Met (5, 12),; 1 for T101I (6)).Although the homology of the mutant residues (Arg89Cys) was not highly conserved, the mutant locus is localized in the immunoglobulin-like domain (IgV-like domain) and the transmembrane domain for TIM-3 protein (5),suggesting Arg89Cys mutation plays important role in modulating immune functions and facilitating disease penetrance. Here, HAVCR2 is linked to subcutaneous panniculitis-like T-cell lymphoma.