HAVCR2 and B-cell non-Hodgkin lymphoma: In order to determine whether TIM-3 mutations were specific to T-cell lymphoma, we randomly chosen 104 of patients(including case1 and case2) with lymphoma (B-cell lymphoma: 79,T-cell lymphoma: 25 where 4 cases complicated with hemophagocytic lymphohistiocytosis),and evaluated the incidence rate of Tyr82Cys and Arg89Cys mutations in somatic cells.