A search for the mutation in 87 population-based healthy controls and 104 cases with B-,or T- cell lymphoma revealed that two cases had heterozygous mutations (1.92%) in the TIM-3 gene, furthermore, only limited in T-cell lymphoma; In healthy controls, the incidence of TIM-3 mutations was 0.00% (0/87),suggesting heterozygous mutations in TIM-3 gene are not a polymorphism,but a pathogenic mutation, as well as susceptible to T-cell lymphoma. This evidence concerns the gene HAVCR2 and T-cell non-Hodgkin lymphoma.