HAVCR2 and T-cell non-Hodgkin lymphoma: In our investigation, 87 of healthy individuals were detected for TIM-3 variants, the result indicated that the TIM-3 mutations were negative(0/87),suggesting a heterozygous Tyr82Cys or Arg89Cys mutation observed in our patients is not a common polymorphism, but a related mutation that could possibly underlie T cell lymphoma.