Her histopathologic, immunohistochemical and T-cell receptor rearrangement(TCR-γ) supported the diagnosis of cutaneous T cell lymphoma.Sanger sequencing indicated the patient harboring a heterozygous Tyr82Cys mutation in TIM-3 gene both involved somatic and germline cells. Here, TRGC1 is linked to primary cutaneous T-cell non-Hodgkin lymphoma.