HAVCR2 and subcutaneous panniculitis-like T-cell lymphoma: The TIM-3, as a negative checkpoint regulator, plays a critical role in innate immunity and inflammatory responses (17, 18).It have been shown that TIM-3 is able to inhibit effector T cell responses by decreasing interferon-γ(IFN-γ)-driven inflammation (17),and the defects of TIM-3 function may explain the HLH manifestations seen in TIM-3-mutant SPTCL (5).