ESR1 and breast cancer: Compared with the inhibition concentration IC5050 of TAM at 41.06 μM in HCC1937 treated with TAM alone for 24 h, IC50 was reduced to 21.26 μM with a combinatory treatment of TAM and MG149 for 24 h (Figure 7D), suggesting that MOF inhibitor MG149 could effectively improve the response of ERα− BC cells to TAM treatment by the restoration of ERα protein abundance.