Of the 120 cases of grade ≥3 TRAEs that occurred in the nICI combination cohort, the leading cause was neutropenia (n = 30; 25.0%), followed by AST/ALT increase (n = 12; 10.0%), pneumonia/pneumonitis (n = 8; 6.7%), and fatigue (n = 8; 6.7%); three grade 5 TRAEs were observed (two cardiopulmonary events and one ARDS). The gene discussed is GPT; the disease is susceptibility to pneumonia measurement.