Yin Yang 1 (YY1), a zinc-finger transcription factor involved in polycomb protein recruitment and transcription regulation (72, 73), is necessary for maintenance of the stem cell phenotype in GBM, is associated with Sox2 and Oct4 expression across cancers (74–77), and mediates both chemotherapy and radiation resistance in GBM (74, 78). The gene discussed is YY1; the disease is cancer.