Dilated cardiomyopathy, the glutathione metabolism, peroxisome and glycosphingolipid biosynthesis, vascular smooth muscle contraction, focal adhesion, cGMP−PKG, calcium signaling, TGF beta signaling pathways, muscle organ development, cytoskeleton organization, muscle contraction biological process CXXC4, and CDK18-ERK1/2 axis. This evidence concerns the gene CXXC4 and dilated cardiomyopathy.