The SMARCA4 (BRG1) subunit, as well as neuron-specific SWI/SNF subunits BAF53B, BAF45B, and CREST, are significantly overexpressed in NEPC compared to CRPC adenocarcinoma, thus positioning SWI/SNF as a regulator of lineage plasticity (84). The gene discussed is SMARCA4; the disease is adenocarcinoma.