Finally, the well-known role of some Interleukins (IL) as pro-angiogenic chemokines has led to the identification of IL-8 as a potential biomarker of angiogenesis in gastric cancer by inducing the overexpression of the VEGF-A, and the receptor isoforms VEGFR-1, and VEGFR-2 (96). This evidence concerns the gene FLT1 and gastric cancer.