ERBB2 and neoplasm: The authors investigated both molecular characteristics on tumor tissue (e.g. EBV, MMR, EGFR, HER2, C-MET) and circulating biomarkers (VEGF, VEGFR-2, neuropillin-1, IL-8, and PIGF) before and after treatment in a subset of patients 44 and 14 patients, respectively.