COMT and Ochoa syndrome: There are a series of factors participate in the regulation of cell proliferation and apoptosis, such as proliferating cell nuclear antigen (PCNA), cyclin-dependent kinase 1 (CDK1), M-phase promoting factor and catechol-O-methyltransferase (COMT), etc., Overexpression of these factors can promote the development of UFs by stimulating cell proliferation, which showing that vitamin D compounds can significantly inhibit the activation of enzymes that regulate factor expression and down-regulate the expression of them (Sharan et al., 2011).