Our findings indicated that DEDD2, GTF2H5, SNRPA1, BICD1, CELF1, and CLK3 were prognostic risk factors for colon cancer, while ADAD1, CMTR1, HNRNPUL1, FTSJ3, WDR43, THUMPD3, SNRPF were prognostic protective factors. Here, BICD1 is linked to malignant colon neoplasm.