SHC1 and congenital bilateral aplasia of vas deferens from CFTR mutation: SHC1 is a member of SHC family of adaptor proteins. SHC1 functions in production of reactive oxygen species. Oxidative stress can cause inflammation and play an important role in the development of CAVD. SHC1 mediated-reactive oxygen species production is closely related to development of atherosclerosis and coronary heart disease