PTPN6 specially expressed in the cytoplasm, it can prevent excessive autoimmunity in IL-1 dependent inflammatory diseases. PTPN6 can ameliorate inflammatory diseases by decreasing TNF-α, TGF-β and IL-6 and prevent the harmful effects of pathogens on the host. PTPN6 is known as an important negative regulator of inflammatory response and down regulated in patients with CAVD. Here, TGFB1 is linked to congenital bilateral aplasia of vas deferens from CFTR mutation.