PTPN11 and pulmonary valve stenosis: PTPN11 is an important component in growth factor pathway and closely related to formation of valve endothelial cells. Moreover, PTPN11 can reduce the level of Th1 cytokine through preventing combination of STAT1 and IFN-γreceptor. PTPN11 is associated with inflammatory diseases, including pulmonary valve stenosis, ulcerative colitis, inflammation induced-myocardial hypertrophy and cardiac fibrotic remodeling