IL1B and congenital bilateral aplasia of vas deferens from CFTR mutation: PTPN6 specially expressed in the cytoplasm, it can prevent excessive autoimmunity in IL-1 dependent inflammatory diseases. PTPN6 can ameliorate inflammatory diseases by decreasing TNF-α, TGF-β and IL-6 and prevent the harmful effects of pathogens on the host. PTPN6 is known as an important negative regulator of inflammatory response and down regulated in patients with CAVD.