At least three groups of melanoma samples could be clustered regarding their TME profile estimates: one with a great proportion of CD4+ T cells and “High_SRPK” malignant cells; a second group with a great proportion of myeloid and natural killer (NK) cells, and a high proportion of “Low_SRPK” malignant cells; and a third group with a high proportion of “High_SRPK” malignant cells and CD8+ T cells. Here, CD4 is linked to melanoma.