Figure 4A showed that tumor tissues with post-operative radiation therapy failure had higher expression of upregulated radioresistant genes FN1, SOX4 and ETV5, while none of the downregulated radioresistant genes were downregulated simultaneously (Figure 4B). Therefore, we speculated that high expression of FN1, SOX4 and ETV5 might be important biomarkers of HNSCC radioresistance. The above three proteins affected the radiosensitivity of HNSCC in vivo. Here, SOX4 is linked to head and neck squamous cell carcinoma.