The differences we see in phenotype may be explained by Krtcap3 having a larger effect size in females relative to males, which is supported by literature on sex-specific obesity loci, where loci explain more variance in women than men (Heid et al., 2010; Shungin et al., 2015). Here, KRTCAP3 is linked to obesity due to melanocortin 4 receptor deficiency.