Yoon et al. study showed that the co-treatment of Huh7 cells, a permanent HCC cell line, with TRT-0173 or TRT-0029, as TRAIL sensitizers, resulted in TRAIL-induced apoptosis because of suppression of the TIPRL-MKK-7 interaction and subsequent phosphorylation of MAP kinase 7 (MKK-7) and c-Jun N-terminal kinase (JNK). Here, MAPK8 is linked to hepatocellular carcinoma.