HIF1A and cancer: In KEGG pathway analysis, the top three pathways were “glycolysis/gluconeogenesis,” “central carbon metabolism in cancer,” and “HIF-1 signaling pathway,” the former two pathways are essential for cellular processes, because they are energy providers (Wong et al., 2017), while the latter pathway is a well-known signaling pathway involved in many physiological and pathological processes in the body and is reportedly associated with EMs (Zhou et al., 2018).