There are three SNPs, rs1229984 in ADH1B at 4q23, rs1789924 near ADH1C at 4q23, and rs671 in ALDH2 at 12q24, significantly associated with the risk of ESCC in the Chinese population (Gao et al., 2013). This evidence concerns the gene ALDH2 and esophageal squamous cell carcinoma.