ATP6V1C2 showed a significantly higher level in metastatic COAD (stage IV) than that in early-stage COAD (stage I) (p = 0.046, Figure 4A) according to the TCGA COAD dataset, which indicated that ATP6V1C2 might be involved in COAD metastasis. The gene discussed is ATP6V1C2; the disease is colon adenocarcinoma.