STAT3 and colorectal carcinoma: Interestingly, scRNA sequencing analysis revealed that these gene sets were enriched in these immune cells whose infiltration levels were significantly elevated in CRC tissues and in CRC patients of cluster-2, including HALLMARK_INFLAMMATORY_RESPONSE, HALLMARK_COMPLEMENT, HALLMARK_INTERFERON_GAMMA_RESPONSE, HALLMARK_INTERFERON_ALPHA_RESPONSE, HALLMARK_ALLOGRAFT_REJECTION, HALLMARK_IL6_JAK_STAT3_SIGNALING, HALLMARK_IL2_STAT5_SIGNALING, and HALLMARK_INFLAMMATORY_RESPONSE (Figure 6D).