As shown in Figure 7F, the infiltrated CD8+T cells in CRC tissues were naïve CD8+ T cells (CD8Tn) and after ICB treatment, more central memory CD8+ T cells (CD8Tcm), effective CD8+ T cells (CD8Teff), and exhausted CD8+ T cells (CD8Tex) were enriched in tumor tissues. This evidence concerns the gene CD8A and neoplasm.