Moreover, KEGG pathway analysis demonstrated that part DEGs in GSE17536 and GSE39582 both participated in immune-related signaling pathways, such as TNF signaling pathway, natural killer cell-mediated cytotoxicity, PD-L1 expression and PD-1 checkpoint pathway in cancer, and chemokine receptor interaction (Figure 4D, Supplementary Figure S2D). This evidence concerns the gene TNF and cancer.