MTHFR and infarction: According to the results of the Spearman correlation analysis shown in Table 3, a weak positive correlation was observed between the severity of white matter lesions and women gender (p = 0.010), previous coronary heart disease (p = 0.008), luminal infarction (p = 0.001), plasma Hcy level (p = 0.029), and MTHFR TT genotype (p = 0.003).