Participants who developed postoperative delirium had higher median preoperative plasma concentration of homocysteine [15.43 (12.23, 21.26) mmol/L versus 12.51 (10.42, 16.32) mmol/L, P = 0.036] and postoperative plasma concentration of CRP [61.60 (40.48, 106.31) mg/L versus 46.50 (27.60, 78.20), mg/L, P < 0.001] than the participants without postoperative delirium (Table 1). The gene discussed is CRP; the disease is delirium.