Loganin could inhibit M1 polarization and modulate the sirt1/NF-κB signaling to attenuate ulcerative colitis [25], and dopamine receptor D5 signaling could downregulate NF-κB signaling to modulate colonic M1/M2 macrophage polarization in colitis [26]. Here, NFKB1 is linked to ulcerative colitis.