DRD4 and α2AR co-localize in cortical pyramidal neurons to form α2AR-D4R heteromers which play a pivotal role in catecholaminergic signaling in the brain cortex and are potential targets for ADHD pharmacotherapy (Casadó-Anguera et al., 2021). The gene discussed is ADORA2A; the disease is attention deficit-hyperactivity disorder.