In the present study, the involvement of HMOX1 in macrophage ferroptosis in response to a mycobacterial infection was interrogated by transcriptome analysis of peripheral blood in TB patients, and its mechanism in ferroptosis was further investigated in mice and macrophage-like RAW264.7 cells by infection of Bacillus Calmette-Guerin (BCG). The gene discussed is HMOX1; the disease is infection.