Moreover, HO-1 is also considered as one of the biomarkers for the diagnosis of TB in clinical settings (Rockwood et al., 2017; Yong et al., 2019; Uwimaana et al., 2021; Yang et al., 2022); whether it plays a role in the regulation of Mtb-induced ferroptosis in macrophages, however, has yet been investigated. The gene discussed is HMOX1; the disease is tuberculosis.