Firstly, pan-cancer analysis (Figure 2(g)) revealed that MMP-3, a member of the matrix metalloproteinase family, was overexpressed in many types of solid tumors, including breast cancer (BRCA), cervical cancer (CESC), bile duct cancer (CHOL), colon cancer (COAD), esophageal cancer (ESCA), and pancreatic cancer (PAAD). This evidence concerns the gene MMP3 and esophageal cancer.