Wang et al. [63] found that “olfactory three needle” at “Yintang” (GV29), bilateral “Yingxiang” (LI20) can activate the PI3K-AKT signaling pathway, upregulate the expression of PSD-95, SYN, and GAP43 proteins, improve synaptic plasticity in Aβ1-42-treated rats, reduce apoptosis, and alleviate memory impairment. Here, AKT1 is linked to memory impairment.