Similarly, BDNF overexpression in 5× familial AD (5-FAD) mice promoted the recovery of SYN and postsynaptic density protein-95 (PSD-95) as well as the number of presynaptic vesicles at excitatory synapses, enhanced long-term potentiation (LTP), and thus improved memory impairment [32]. The gene discussed is DLG4; the disease is memory impairment.