MTOR and memory impairment: Similarly, acupuncture at the corresponding acupoints can inhibit GSK3β/mTOR in d-galactose-treated rats [65] and the AMPK/eEF2K/eEF2 [66] and RhoA/ROCK signaling pathways in SAMP8 mice to promote synaptic plasticity, thereby improving memory impairment [67].