Wang et al. [74] used EA with different frequencies (2 Hz and 50 Hz) to stimulate “Baihui” (GV20) and “Shenshu” (BL23) and found that high-frequency EA can enhance the expression of the NMDAR subunit gene, increase the number of hippocampal synapses, and reduce APP, Aβ1-40, and Aβ25-35 protein levels, thereby improving memory impairment. The gene discussed is APP; the disease is memory impairment.