In addition, the study by Hou et al. [64] showed that EA at “Baihui” (GV20), bilateral “Zusanli” (ST36) could improve the memory impairment in SAMP8 mice, and that its mechanism was related to activation of cAMP/PKA/CREB signaling pathway and enhancing synaptic plasticity of hippocampal neurons. This evidence concerns the gene CREB1 and memory impairment.