PPAR and LXRα agonists can upregulate the expression of macrophage ABCA1/ABCG1, promote apoA-I-mediated cholesterol efflux, enhance the burial effect of apoptotic cells in the body, and reduce the formation of atherosclerosis in the body [13, 14] and can already be used as oral preparations. Here, NR1H3 is linked to atherosclerosis.