For example, low expression of UGP2 is associated with HCC progression [53]; RAN promotes the growth, migration, and invasion of HCC cells [54]; ITGAV is up-regulated in HCC and promotes tumor metastasis [55]; ETFDH is underexpressed in HCC and associated with poor OS [56]; and SERPINA3 mediates the upregulation of HNRNP-K transcriptional activity and promotes the survival and proliferation of HCC cells [57]. The gene discussed is UGP2; the disease is hepatocellular carcinoma.