A previous multicenter study comparing serum GOLM1 and alpha-fetoprotein (AFP) in 4217 human subjects showed that GOLM1 had a sensitivity and specificity of 76.4% and 97.4%, respectively, for HCC, while AFP had a sensitivity and specificity of 58.2% and 85.3%, respectively [8]. This evidence concerns the gene AFP and hepatocellular carcinoma.