BTD and urinary system disorder: As shown in Table 4, DEPs were enriched to 15 functional categories involving renal and urological disease with statistical significance, including renal vein thrombosis, migration, atypical hemolytic uremic syndrome (aHUS), failure, biotinidase deficiency, septic acute kidney injury, staghorn calculus, susceptibility to aHUS type 5, end stage renal disease (ESRD), aHUS, adhesion, acute tubular necrosis, C3 glomerulopathy, nephrosis, and membranoproliferative glomerulonephritis.