As shown in Table 4, DEPs were enriched to 15 functional categories involving renal and urological disease with statistical significance, including renal vein thrombosis, migration, atypical hemolytic uremic syndrome (aHUS), failure, biotinidase deficiency, septic acute kidney injury, staghorn calculus, susceptibility to aHUS type 5, end stage renal disease (ESRD), aHUS, adhesion, acute tubular necrosis, C3 glomerulopathy, nephrosis, and membranoproliferative glomerulonephritis. The gene discussed is BTD; the disease is complement 3 glomerulopathy.