Cytokines have emerged as playing an important, albeit poorly understood, role in tumor progression.50 When we evaluated peripheral cytokine levels in MC38-CEA tumor-bearing mice 14 days after tumor instillation, we noted increased levels of IL-1β in animals receiving αTIGIT + bintrafusp alfa that responded to therapy (Figure 5a). The gene discussed is IL1B; the disease is neoplasm.