Therefore, in the current study, we compared the cost-effectiveness of domestic ensartinib vs. all imported ALK-TKIs (crizotinib, ceritinib, alectinib, brigatinib, and lorlatinib) that are recommended by the CSCO Guidelines as a first-line treatment for advanced ALK-positive NSCLC. This evidence concerns the gene ALK and non-small cell lung carcinoma.