ALK and non-small cell lung carcinoma: To our best knowledge, this is the first cost-effectiveness analysis studying the first domestic ALK-TKI ensartinib approved as a frontline therapy for Chinese patients with advanced ALK-positive NSCLC, and it is also the first one to investigate all the six ALK-TKIs (ensartinib, crizotinib, ceritinib, alectinib, brigatinib, and lorlatinib) recommended by the CSCO Guidelines for treating advanced ALK-positive NSCLC in Chinese patients.