APOE and atherosclerosis: Huang et al. (98) reported that IL-12p35 deficiency decreased IL-35 levels and inhibited Treg production and function in ApoE−/− mice, while IL-12p35 deficiency was followed by increased Th17-cell levels and IL-17 levels, thereby exacerbating the Th17/Treg imbalance and promoting atherosclerosis.