Mallat et al. (66) studied IL-10−/− and IL-10+/+ C57BL/6J mice and found that compared to the IL-10+/+ mice, the IL-10−/− mice demonstrated a significant 3-fold increase in aortic sinus atherosclerotic lesions and lesions expressing higher levels of IFN-γ, increased activated T cell infiltration, and decreased collagen levels, which increased atherosclerosis while decreasing atheromatous plaque stability, suggesting an important atheroprotective role of IL-10. The gene discussed is IFNG; the disease is atherosclerosis.