APOE and atherosclerosis: In contrast, Gao et al. (60) performed selective transfer of CD4+FOXP3(GFP)+ Tregs into the aorta of ApoE−/− mice and observed that the Treg transmigration reduced the aortic facial atheroma plaque area by 54.3% (P < 0.001) and the aortic root plaque area by 34.0%, (P < 0.001) and significantly reduced macrophage infiltration (65.2%, P < 0.001), suggesting the important role of Tregs in atherosclerosis development.