Similarly, Fourman et al. (68) measured IL-10 in serum samples with enzyme-linked immunosorbent assay and assessed coronary atherosclerosis using computed tomography angiography in an observational study of human immunodeficiency virus (HIV) patients and uninfected controls, and found that reduced IL-10 was associated with increased coronary plaque incidence and increased carotid intima-media thickness, suggesting a protective effect of IL-10 against atherosclerosis in HIV. This evidence concerns the gene IL10 and coronary atherosclerosis.