Abbas et al. (36) reported that IL-23 and IL-23R expression was increased in carotid atherosclerotic plaques and that IL-23 induced a significant increase in the release of IL-17 from the cells of patients with carotid atherosclerosis and accelerated their inflammatory state, suggesting that IL-23 may promote the development of atherosclerosis through the IL-23–IL-17 axis. This evidence concerns the gene IL23R and atherosclerosis.