Conversely, Liu et al. (69) used adeno-associated virus type 2 (AAV) vector transduction of IL-10 in Ldlr−/− mice to upregulate IL-10 gene and protein expression and observed reduced subintimal lipid accumulation and lower CD68 and reactive oxygen species levels, suggesting that systemic AAV vector transduction of the IL-10 gene could suppress inflammation and oxidative stress, thereby inhibiting atherosclerosis. Here, IL10 is linked to atherosclerosis.