The dysfunction in psoriasis includes systemic inflammation involving cytokines, such as IL-17, TNF-α and IFN-γ (42), as well as inflammatory transcripts such as CXCL10, IL-1β and VCAM-1.Psoriasis increases vascular stiffness and atherosclerosis tthrough the IL-17 pathway (43). The gene discussed is IL1B; the disease is atherosclerosis.