FGFR1 and heart failure: Interestingly, chronic overexpression of a constitutively activated FGFR1 in cardiomyocytes (CM-caFGFR1) resulted in significant myocardial hypertrophy, pathological remodeling (myocyte disarray and fibrosis), reduced cardiomyocyte relaxation and potential long term diastolic heart failure (28).