A significant interaction between the intervention and the subgroup levels except baseline HbA1C level ≤ 8.1 vs. >8.1% years (p < 0.001) were observed, a marginal interaction was observed for (left ventricular ejection fraction) LVEF (p = 0.027), but not for other subgroup age ≤ 65 vs. >65 years (p = 0.859), men vs. women (p = 0.362), resident vs. other (p = 0.372), hypertension yes vs. no (p = 0.072), diabetes duration < 10 vs. ≥10 years (p = 0.685), not smoking vs. current smoker (p = 0.226), BMI < 25 vs. ≥25 (p = 0.552), and insulin usage vs. no insulin (p = 0.666), respectively (Table 2). This evidence concerns the gene INS and diabetes mellitus.