By combining inflammation-related indexes (counts of lymphocyte, monocyte, neutrophil and platelet; concentration of C-reactive protein) and liver function parameters [levels of bilirubin, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and gamma-glutamyl transpeptidase (GGT)], several prognostic scores including the Glasgow Prognostic Score (GPS), Prognostic Nutritional Index (PNI), and lymphocyte-C-reactive protein ratio (LCR) were introduced and validated in predicting outcomes of ICC patients following surgical treatments (28, 29). This evidence concerns the gene CRP and intrahepatic cholangiocarcinoma.