On the other hand, VEGF has also been implicated in the etiology of various neurological diseases, since it is also associated with vascular permeability, which can compromise nervous system and blood-brain barrier homeostasis, promoting the production of reactive oxygen species, migration of immunological cells and inflammation in humans and animals (81, 82), which contributes to vascular aging and age-related frailties and diseases. This evidence concerns the gene VEGFA and nervous system disorder.