CDC73 and tumor of parathyroid gland: The parafibromin/PAF1 complex was found to directly regulate genes related to cell growth and survival, including H19, Hmga1, Hmga2, Hmgcs2, Igf1, Igf2, and Igfbp4. The mice with parathyroid-specific deletion of CDC73 developed parathyroid tumors and could be used as an animal model of HPT-JT syndrome (Walls et al., 2017), and CDC73 loss in hematopoietic cells was lethal because cell cycle defects in hematopoietic progenitors resulted in bone marrow failure (Saha et al., 2019).