The parafibromin/PAF1 complex was found to directly regulate genes related to cell growth and survival, including H19, Hmga1, Hmga2, Hmgcs2, Igf1, Igf2, and Igfbp4. The mice with parathyroid-specific deletion of CDC73 developed parathyroid tumors and could be used as an animal model of HPT-JT syndrome (Walls et al., 2017), and CDC73 loss in hematopoietic cells was lethal because cell cycle defects in hematopoietic progenitors resulted in bone marrow failure (Saha et al., 2019). This evidence concerns the gene CDC73 and Bone marrow hypocellularity.