As a key epithelial cell polarity determinant, Scrib is crucial in preserving epithelial integrity, since its loss gives rise to neoplasia (Bilder, 2004; Zeitler et al., 2004; Hariharan and Bilder, 2006; Bonello and Peifer, 2019; Khoury and Bilder, 2020). Here, SCRIB is linked to neoplasm.