In the Systemic lupus erythematosus (SLE) mouse model, Bcl6FC mice develop a strong elevation of auto-reactive IgA titers, which resembles the high titers of IgA anti-dsDNA antibodies in patients with SLE that cause joint abnormalities and kidney injury (Villalta et al., 2013). The gene discussed is CD79A; the disease is systemic lupus erythematosus.