Regarding Cd6-/- mice, no analysis of DSS-induced colitis has been brought forward, in spite of reports of Cd6-/- mice behavior in several other immune-related inflammatory disease models (i.e., intestinal ischemia-reperfusion, bovine or avian type II collagen-induced arthritis, chronic graft-versus-host disease-induced lupus-like, imiquimod-induced psoriasis-like skin inflammation, experimental autoimmune encephalitis, and autoimmune uveitis) (10, 34, 39, 59–62). This evidence concerns the gene CD6 and Arthritis.