Allelic combinations of the CD5 rs2241002 and rs2229177 SNPs resulting in hyper-reactivity to TCR stimulation are associated to more severe systemic lupus erythematosus (SLE) forms, but predict better prognosis in chronic lymphocytic leukemia (CLL) and melanoma (27–29). The gene discussed is CD5; the disease is B-cell chronic lymphocytic leukemia.