IGHE and chronic idiopathic urticaria: This is true also in the setting of chronic spontaneous urticaria, where low total IgE is a strong predictor of poor response (64, 65), but specific IgE levels against a number of autoallergens (e.g., Fc epsilon R1, IL-24 and others) also may have some role in response prediction - although the evidence at the moment is conflicting (66).