We identified TFs, such as GATA3, STAT3, STAT1, CEBPB, FOS, FOXD1, MAX, GATA2, RELA, and JUN, which are associated with diffident types of respiratory diseases, such as asthma, COPD, IPF, and COVID-19 (88, 91–100). This evidence concerns the gene JUN and chronic obstructive pulmonary disease.