We identified TFs, such as GATA3, STAT3, STAT1, CEBPB, FOS, FOXD1, MAX, GATA2, RELA, and JUN, which are associated with diffident types of respiratory diseases, such as asthma, COPD, IPF, and COVID-19 (88, 91–100). The gene discussed is STAT3; the disease is chronic obstructive pulmonary disease.