We used the MCC method to identify the top 15 hub genes (MX1, RSAD2, IFIT3, OAS1, OAS2, IFIT1, IFIH1, IFI6, IFIT2, IFI27, OAS3, SAMD9L, CMPK2, IFI35, and IFNL1) associated with both asthma and COVID-19. The gene discussed is CMPK2; the disease is COVID-19.