Of these patients, three had SCID (1 Artemis, 2-RAG1), four had CVID, three had AIRE, one had DOCK8 deficiency, one had IPEX syndrome, one had CGD, one had STAT1, and one had PIK3CD. The gene discussed is DOCK8; the disease is immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.