CD8A and autoimmune disease: (3, 43) showed that the transcriptional signature of T-cell exhaustion is associated with self-protection during relapse in a variety of autoimmune diseases by constructing a model of in vitro co-stimulation of human primary CD8+ T-cells in which the CD8+ T-cells were activated in the presence or absence of antibody-mediated CD2 stimulation (using beaded polyclonal anti-CD3/28 antibodies).