CD4 and neoplasm: By investigating the level of immune cells infiltration in the TME, we observed two main features: 1) high-risk subgroup had lower immunoreactivity, 2) major lymphocyte subsets involved in anti-tumor immunity, including CD4+ memory T cells, CD4+ Tcm, CD8+ T cells, DCs, macrophages, mast cells, NKT cells, and Tregs were significantly absent in the high-risk subgroup.